Russian Biomedical Research (Российские биомедицинские исследования)

ГЛУБОКИЕ ЭВТЕКТИЧЕСКИЕ РАСТВОРИТЕЛИ — НОВЫЙ СПОСОБ ТРАНСДЕРМАЛЬНОЙ ДОСТАВКИ ЛЕКАРСТВ

  • Елена Владимировна Андрусенко Военно-медицинская академия им. С.М. Кирова. 194044, г. Санкт-Петербург, ул. Академика Лебедева, 6 https://orcid.org/0000-0003-0588-4960
  • Александра Дмитриевна Гершон Российский государственный педагогический университет им. А. И. Герцена. 191186, Российская Федерация, г. Санкт-Петербург, наб. реки Мойки, 48–52, лит. А
  • Руслан Иванович Глушаков Военно-медицинская академия им. С.М. Кирова. 194044, г. Санкт-Петербург, ул. Академика Лебедева, 6
Ключевые слова:
глубокие эвтектические растворители трансдермальная доставка лекарств вакцина активная фармацевтическая субстанция deep eutectic solvents transdermal drug delivery vaccine active pharmaceutical substance

Аннотация

Системы трансдермальной доставки лекарственных средств имеют ряд преимуществ благодаря неинвазивному введению и особенностям фармакокинетики, что делает данный способ крайне привлекательным в педиатрической практике. Фармакокинетические преимущества заключаются в повышении биологической доступности из-за отсутствия эффекта первичного прохождения через печень, равномерного поступления действующего вещества в системный кровоток, благодаря чему кривая концентрации лекарственного вещества приобретает более равномерный характер. На данный момент в мире в качестве систем трансдермальной доставки используются пластыри, однако глобальные сложности правоприменительной практики вывода препаратов для акушерской и педиатрической аудитории на рынок лимитируют возможности создания трансдермальных терапевтических систем. В данном обзоре рассмотрены системы трансдермальной доставки лекарственных средств на основе глубоких эвтектических растворителей. Благодаря своим уникальным свойствам, таким как простота синтеза, низкая токсичность и стоимость, высокая стабильность и биосовместимость, глубокие эвтектические растворители являются привлекательными системами доставки активных фармацевтических субстанций для применения в педиатрии.

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WO2019122329 LIQUID VACCINES OF LIVE ENVELOPED

VIRUSES [Электронный ресурс]. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019122329 (дата обращения: 04.10.2023).

Как цитировать
ГЛУБОКИЕ ЭВТЕКТИЧЕСКИЕ РАСТВОРИТЕЛИ — НОВЫЙ СПОСОБ ТРАНСДЕРМАЛЬНОЙ ДОСТАВКИ ЛЕКАРСТВ. (2024). Russian Biomedical Research (Российские биомедицинские исследования), 8(4), 65-73. https://doi.org/10.56871/RBR.2023.27.50.008
Выпуск
Том 8 № 4 (2023)
Раздел
Статьи
Опубликован
2024-05-15

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Как цитировать

ГЛУБОКИЕ ЭВТЕКТИЧЕСКИЕ РАСТВОРИТЕЛИ — НОВЫЙ СПОСОБ ТРАНСДЕРМАЛЬНОЙ ДОСТАВКИ ЛЕКАРСТВ. (2024). Russian Biomedical Research (Российские биомедицинские исследования), 8(4), 65-73. https://doi.org/10.56871/RBR.2023.27.50.008

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