Создание продуктов на основе внеклеточных везикул из мезенхимальных стволовых клеток: ИННОВАЦИОННАЯ ФАРМАКОЛОГИЯ

Родион Владимирович  Кораблев; Андрей Глебович  Васильев; Сарнг Саналович  Пюрвеев; Татьяна Викторовна  Брус; Александра Юрьевна  Пырх; Анна Евгеньевна  Куртукова; Юлиан Рэммович  Рыжов; Юлия Александровна  Таминкина; Заур Келбялиевич  Эмиргаев

doi:10.56871/RBR.2026.14.44.006

Constructing products based on extracellular vesicles obtained from mesenchymal stem cells

INNOVATIVE PHARMACOLOGY

Rodion V. Korablev Saint Petersburg State Pediatric Medical University https://orcid.org/0009-0004-5754-8437
Andrei G. Vasiliev Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-8539-7128
Sarng S. Pyurveev Saint Petersburg State Pediatric Medical University; Institute of Experimental Medicine https://orcid.org/0000-0002-4467-2269
Tatyana V. Brus Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-7468-8563
Alexandra Yu. Pyrkh Saint Petersburg State Pediatric Medical University https://orcid.org/0009-0001-4761-5076
Anna E. Kurtukova Saint Petersburg State Pediatric Medical University https://orcid.org/0009-0008-7985-782X
Yulian R. Ryzhov Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott https://orcid.org/0000-0002-5073-8279
Yulia A. Taminkina Trans-Tehnologies LTD https://orcid.org/0000-0001-5256-9360
Zaur K. Emirgaev City Hospital of Saint Holy Martyr Elizabeth https://orcid.org/0000-0002-8143-0461

Keywords:

mesenchymal stem cells mesenchymal stem cell secretome extracellular vesicles exosomes extracellular vesicle-based products мезенхимальные стволовые клетки секретом мезенхимальных стволовых клеток внеклеточные везикулы экзосомы продукты на основе внеклеточных везикул

Abstract

Mesenchymal stem cells and products based on it are an effective means of treating diseases due to their proven effect on the tissue reparation. In recent years, large amount of data has accumulated showing that the therapeutic effect of mesenchymal stem cells is realized not by the cells themselves, but by it secretome. Preclinical studies usingin vitroandin vivodisease models have demonstrated promising results with small extracellular vesicles derived from stem cells, including mesenchymal stem cells: reduction of oxidative stress, increased proliferation, survival and differentiation of cells, suppression of inflammation, which promotes regeneration at the site of damage. Isolation of the vesicular fraction of mesenchymal stem cells is the starting point for the production of products based on it. However, the path from the idea to the registration of such products is associated with many difficulties. A therapeutic strategy that allows achieving the effects of cell therapy without mesenchymal stem cells transplantation offers a number of advantages. The aim of this review is to highlight the multiple factors that contribute to the high variability of the vesicular fraction obtained from mesenchymal stem cells, the challenges of developing cell-free products, and the need for standardized protocols for the production and evaluation of extracellular vesicles.

Author Biographies

Rodion V. Korablev, Saint Petersburg State Pediatric Medical University

Cand. Sci. (Med.), Associate Professor, Department of Pathological Physiology with a Course of Immunopathology

Andrei G. Vasiliev, Saint Petersburg State Pediatric Medical University

Dr. Sci. (Med.), Professor, Head of the Department of Pathological Physiology with a Course of Immunopathology

Sarng S. Pyurveev, Saint Petersburg State Pediatric Medical University; Institute of Experimental Medicine

Cand. Sci. (Med.), Associate Professor of the Department of Pathological Physiology with a Course of Immunopathology, Saint Petersburg State Pediatric Medical University; Junior Research, Department of Neuropharmacology named after S.V. Anichkov, Institute of Experimental Medicine

Tatyana V. Brus, Saint Petersburg State Pediatric Medical University

Cand. Sci. (Med.), Associate Professor, Department of Pathological Physiology
with a Course of Immunopathology

Alexandra Yu. Pyrkh, Saint Petersburg State Pediatric Medical University

Assistant, Department of Pathological Physiology with a course in Immunopathology

Anna E. Kurtukova, Saint Petersburg State Pediatric Medical University

4th-year student at the Faculty of Pediatrics

Yulian R. Ryzhov, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Cand. Sci. (Med.), Head of Assisted Reproductive Technologies

Yulia A. Taminkina, Trans-Tehnologies LTD

Biophysicist

Zaur K. Emirgaev, City Hospital of Saint Holy Martyr Elizabeth

Urologist of the Urology Department

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Constructing products based on extracellular vesicles obtained from mesenchymal stem cells: INNOVATIVE PHARMACOLOGY. (2026). Russian Biomedical Research, 11(1), 54-66. https://doi.org/10.56871/RBR.2026.14.44.006

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