EFFECT OF SUCCINE-CONTAINING MEDICINES ON OXYGEN STATUS IN CHILDREN

The positive effects of succinic acid preparations on the acid base state, osmolality and electrolyte composition of plasma in critically ill patients are known. Drugs affect the energy metabolism and oxygen status of the cell. Objective: to study the reactions of the oxygen extraction index and the oxyhemoglobin dissociation curve in children to Reamberin infusion. Material and methods. The study included 39 children 1 year and older in the most acute periods of traumatic brain injury and poisoning with concentrated acetic acid. An intergroup comparison of oxygen status indicators was carried out during emergency rehydration of a 1.5% solution of Reamberin and isotonic Sterofundin in the first hour from the moment of admission. Conclusions. In patients with traumatic brain injury, Reamberin infusion moderately increased oxygen extraction (p=0.02) and counteracted the increase in hemoglobin oxygen affinity (p=0.001). In patients with acetic acid poisoning, Reamberin reduced excess oxygen extraction and leveled the increased affinity of hemoglobin for oxygen (p <0.048).